This is one of the standard treatment schemes recommended by Prof. Dr. Ana Aslan for preventive and curative treatment of old age phenomena: Ampoule series: One injectible ampoule on Monday, Wednesday and Friday in every week of the month for at least 10 ampoules/month. One month break or alternate with one month tablets treatment. About Gerovital: Discovered by Prof. Dr. Ana Aslan at the Geriatric Institute of Bucharest, in early fifties it is produced until now in the Bucharest factory. This unique nutritional formulation has been described as "The Fountain of Youth", and is estimated to be in use by more than 10 million people in more than 70 countries worldwide. Being the first anti-aging therapy, Gerovital H3 reduces free radical activity, preventing damage to DNA and cellular membranes. The complex effects of Gerovital-H3 are, due to its activity, both at the level of the central and neurovegetative nervous systems, and at the level of the cells. The product has been proved to act in the oxidation-reduction phenomena of the cell, stimulation of tissue regeneration and the improvement of metabolic processes. Has been proved that help also in treatment of: Parkinson's, spondylosis, arthritis, osteoporosis, neurodermitis, eczema, alopecia, psoriasis, arteriosclerosis, vitiligo, sclederma and many others.

 Composition:
One ampoule contains:
- Procaine hydrochloride (100 mg)
- Benzoic acid (6 mg)
- Disodium phosphate dodecahydrate (0.5 mg)
- Potassium metabisulfite (5 mg)
- Distilled water for injectable solutions (up to 5 ml)

Therapeutic indications:
DEPRESSIVE SYNDROME: light and moderate depression, in precocious stages, especially when conventional therapy is not well-tolerated or it has contraindications;
PARKINSONIAN SYNDROMES: where it can be used in monotherapy or associated with other antiparkinsonian drugs, especially with dopaminergic agents;
OSTEOARTHRITIS: chronic degenerative rheumatism;
SYSTEMIC ARTERIOSCLEROSIS: with hypercholesterolemia, ischaemic heart disease, arteritis, cerebral atherosclerosis;
PROTECTION AGAINST AGING PHENOMENA;

Posology and method of administration:
Before starting the treatment with Gerovital® H3 it is compulsory to test individual sensitivity to procaine, as follows: 1 ml from the injectable solution of Gerovital® H3 will be administered subcutaneously and after 24 hours the test should be repeated with 1.5 ml solution intramuscularly. If any allergic reaction occurs, the treatment is not recommended.

Contraindications:
*Hypersensitivity to procaine in antecedents or tested.
*Severe arterial hypotension.
*Associated treatment with sulfonamides (except the antidiabetic ones) and with acetylcholinesterase agents: neostygmine, eserine (physostigmine) and pyridostigmine.

Precautions regarding medicinal product administration:
Before starting the treatment, a test for individual tolerance to procaine should be made (see under Posology and method of administration).
The treatment must take place under medical supervision, mainly in the first series of treatment, in order to establish the optimal dose.
The product should be administered with caution in patients with orthostatic hypotension.
Although procaine medication is not carcinogenic, it is not recommended to the patients with cancer, as its stimulating effect on mitotic potential of the neoplasic cell is not excluded.

Interactions with other medicinal products or other substances:
Gerovital® H3 should not be administered simultaneously with sulphonamides (antagonistic mechanism of action) - except the antidiabetic ones, anticholinesterases: neostygmine, eserine (physostigmine) and pyridostigmine.

Special warnings:
Pregnant and breast-feeding women: the studies on animals did not show teratogenic effects. In absence of teratogenic effects on animals, malformative effects on humans are not expected. However, the clinical experience with Gerovital® H3 is mainly on patients over the procreation period. For these reasons we do not recommend the use of the product during pregnancy and lactation.
Potential effect on the ability to drive or to use machines: the product does not interfere with these abilities.

Adverse reactions, which can occur during the use of the medicinal product:
Administration of Gerovital® H3 may produce allergic reactions in patients with hypersensitivity to procaine like skin rash or pruritus.
These effects impose an immediate stop of the treatment.
Minor effects may occur especially at the beginning of the treatment like: dizziness, weakness and palpitations. These effects can be avoided if after the injection the patient rests in bed for 10-15 minutes.

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